Advances in Research on Epithelial-mesenchymal Transition in Colorectal Cancer
10.3969/j.issn.1008-7125.2016.05.013
- VernacularTitle:上皮-间质转化在结直肠癌中的研究进展
- Author:
Chunfeng ZHUGE
;
Shiquan LIU
- Publication Type:Journal Article
- Keywords:
Epithelial-Mesenchymal Transition;
Colorectal Neoplasms;
Molecular Mechanism;
Signal Pathway;
Drug Resistance,Neoplasm
- From:
Chinese Journal of Gastroenterology
2016;21(5):307-310
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a common malignant tumor,and invasion and metastasis are the major causes of death. Epithelial-mesenchymal transition(EMT)occurs along with transition from epithelial phenotype to mesenchymal phenotype. EMT is involved in the genesis,development,invasion and metastasis of various tumors including colorectal cancer. EMT is closely associated with chemotherapy resistance of tumors. Various signaling pathways are involved in the pathogenesis of EMT and its mechanism is not fully clear. This article reviewed the molecular mechanism and role of EMT in colorectal cancer.
