Research progress on the influence of anti-angiogenetic agents on antitumor immuni-ty regulation
10.3969/j.issn.1000-8179.2016.09.184
- VernacularTitle:抗血管生成药物对肿瘤免疫调节影响的研究进展
- Author:
Qingjing LIU
;
Xiaodong JIANG
- Publication Type:Journal Article
- Keywords:
anti-angiogenesis,tumor immune escape;
tumor microenvironment
- From:
Chinese Journal of Clinical Oncology
2016;43(9):400-403
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor therapy has entered a new era ofprecise treatment.Nowadays, targeted anti-angiogenic agents have become a popular research topic that continues to attract increasing interest. Tumor immune escape plays an indispensable role in therapeutic resistance. Anti-angiogenic therapies not only prevent the tumor angiogenesis and suppress tumor growth but also neu-tralize tumor escape from a host's immune system by reducing the immunosuppressive cells and increasing the number of tumor-infil-trating lymphocyte (TIL) and cytotoxic lymphocte (CTL). This paper aims to review the mechanism underlying the manner by which an-ti-angiogenesis enhances immunity by influencing tumor microenvironment.
