Effect of Electroacupuncture with Different Frequencies on Learning and Memory Ability and Synapse in Hippo-camp in Rats with Alzheimer's Disease
10.3969/j.issn.1006-9771.2016.06.003
- VernacularTitle:不同频率电针对阿尔茨海默病大鼠学习记忆能力和海马突触的影响
- Author:
Ying WANG
;
Wei LI
;
Kangkang ZHANG
;
Hui WANG
;
Lihong KONG
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
electroacupuncture;
frequency;
learning and memory ability;
synaptic density;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(6):635-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electroacupuncture with different frequencies on learning and memory ability, synaptic morphology and synaptic density in the hippocampus of Alzheimer's disease rats. Methods Forty-eight healthy Wistar rats were randomly di-vided into normal group, sham operation group, model group, 2 Hz, 30 Hz and 50 Hz electroacupuncture groups with 8 cases in each group. The Alzheimer's disease model was established by injecting Aβ1-42 into two sides of lateral cerebral ventricle. The sham operation group was injected with normal saline instead. The electroacupuncture groups received electroacupuncture at Baihui (DU20) and Shenshu (BL23) acu-points. The learning and memory ability was evaluated with Morris water maze test, and the morphology and density of synapse were ob-served by electron microscope. Results Compared with the model group, the latency was shorter, the time of crossing the platform was short-er and the number of crossing the platform was more in the electroacupuncture groups (P<0.01), especially in the 50 Hz electroacupuncture group (P<0.01). The number of synapse and the synaptic density were more in the electroacupuncture groups than in the model group (P<0.01), especially in the 50 Hz electroacupuncture group (P<0.01). Conclusion Electroacupuncture could improve learning and memory abili-ty and increase synaptic density in rats with Alzheimer's disease, especially with high frequency.
