Expression of asymmetric dimethylarginine in patients with acute cerebral infarction
10.3969/j.issn.1672-5921.2016.05.005
- VernacularTitle:非对称性二甲基精氨酸在脑梗死患者急性期的表达
- Author:
Lei ZHANG
;
Yajun LI
;
Xiangli KONG
;
Shaoting SHI
;
Bei ZHANG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Acute stage;
Asymmetrical dimethylarginine
- From:
Chinese Journal of Cerebrovascular Diseases
2016;13(5):245-248
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum asymmetric dimethylarginine (ADMA)expression in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction admitted to the Department of Neurology,the First Affiliated Hospital of Xi′an Medical College from March 2013 to August 2015 were enrolled retrospectively. According to the National Institutes of Health Stroke Scale (NIHSS)scores,they were divided into three groups:mild infarction (n =21;<4),moderate infarction (n =49;4 -15),and severe cerebral infarction (n = 30;> 15);100 healthy subjects without cerebrovascular disease in the same period were used as a control group. Enzyme linked immunosorbent assay was used to detect the plasma ADMA concentration,and the levels of plasma ADMA among the groups were compared. Results The concentrations of plasma ADMA of the mild,moderate,severe cerebral infarction,and the control groups were 0. 80 ± 0. 16,1. 14 ± 0. 28,1. 33 ± 0. 33,and 0. 52 ± 0. 16 μmol/ L,respectively. There were significant differences among the groups (F = 2. 32,P < 0. 05). Multivariate logistic regression analysis suggested that ADMA was an independent risk factor for cerebral infarction (OR,1. 140,95% CI 1. 078 -1. 212,P = 0. 045). Conclusions The expression levels of plasma ADMA increased gradually in patients with mild,moderate,and severe cerebral infarction. The higher the ADMA levels,the severe the neurological deficit would be. ADMA might be an independent risk factor for cerebral infarction.
