Expression levels and clinical significance of microRNA-451 in the plasma of patients with diffuse large B lymphoma
10.7652/jdyxb201604029
- VernacularTitle:microRNA-451在弥漫性大 B 细胞淋巴瘤患者血浆中的表达及意义
- Author:
Ping ZHANG
- Publication Type:Journal Article
- Keywords:
diffuse large B lymphoma;
microRNA-451;
RT-PCR
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(4):609-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression level and clinical significance of microRNA‐451 (miR‐451) in the plasma of patients with diffuse large B lymphoma (DLBCL) .Methods We enrolled 27 patients with DLBCL and 27 healthy controls for the study .The plasma level of miR‐451 was detected by reverse transcription polymerase chain reaction (RT‐PCR) .Then we analyzed the relationship between the plasma level of miR‐451 and pathological characteristics of DLBCL .Results The plasma level of miR‐451 in the patients with DLBCL was significantly lower than in healthy controls [(0 .41 ± 0 .15) vs .(0 .64 ± 0 .21)] (P<0 .01) .However ,the plasma level of miR‐451 was not significantly correlated with the patients'gender ,age ,serum LDH level or primary site (P>0 .05) ,but with Ann Arbor tumor stage and IPI score ( P< 0 .05 ) .Conclusion The plasma level of miR‐451 decreases in patients with DLBCL ,which indicates that miR‐451 may participate in the pathology of DLBCL .
