Advances in research on molecular mechanisms and target diagnosis of gastric cancer
10.7652/jdyxb201604001
- VernacularTitle:胃癌的分子机制及靶向诊断研究进展
- Author:
Shuixiang HE
;
Dan ZHANG
;
Shaoying LU
- Publication Type:Journal Article
- Keywords:
gastric cancer;
molecular mechanism;
target therapy;
target diagnosis
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(4):461-472
- CountryChina
- Language:Chinese
-
Abstract:
Multiple cellular factors and molecular signal pathways including PI 3K/AKT pathway;MAPK pathway;growth factors and receptors like HER , VEGF/VEGFR and MET ;inflammation‐related factors like COX‐2 ,NF‐κB ,STAT and interleukins ,are involved in the occurrence and development of gastric cancer ,these factors play a key role in apoptosis inhibition ,proliferation promotion and cell cycle regulation of gastric cancer cells ,as well as invasion ,migration and angiogenesis of stomach malignancy .They are also expressed at a higher level in gastric cancer tissue compared with normal gastric mucosa and characterized as biomarkers ,whose target therapies mostly have been in clinical trials . Based on these theoretical foundations , the research on molecular diagnosis of gastric cancer has made some progress .Instruments for target detection tend to be mature .However , the research of molecular probes is still in pre‐clinical trials ,which remains to be further developed .
