Immunophenotyping of myelodysplastic syndromes by flow cytometry and its potential clinical application

VernacularTitle:流式细胞术检测骨髓增生异常综合征免疫表型分析及临床应用前景
Author: Fei WANG ; Shuqin XU ; Wei CUI
Publication Type:Journal Article
Keywords: Myelodysplastic syndromes; Immunophenotyping; Flow cytometry
From: Chinese Journal of Laboratory Medicine 2016;39(5):332-335
CountryChina
Language:Chinese
Abstract: Myelodysplastic syndromes (MDS) is a heterogeneous group of clone bone marrow disorders.The diagnosis of MDS can be challenging when dysplastic features are minimal and cytogenetic analysis shows no abnormalities The high sensitivity of flow cytometry (FCM) in the detection of dysplasia in myeloid lineages makes it a valuable tool to distinguish possible clonal causes of cytopenia(s) from nonclonal causes.Due to the heterogeneity and absence of specific FCM markers for MDS,the immunophenotyping of MDS by FCM remains a big difficulty.Here we will focus on how to perform immunophenotyping of MDS by FCM and the potential diagnostic,prognostic and therapeutic value of FCM in MDS.