Association of uromodulin gene polymorphism with diabetic kidney disease in Han population in Tianjin of China
10.3760/cma.j.issn.1001-7097.2016.05.004
- VernacularTitle:尿调蛋白基因和天津地区汉族糖尿病肾病的相关性
- Author:
Jun GUO
;
Liming CHEN
;
Baocheng CHANG
;
Miaoyan ZHENG
;
Juanjuan WEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Polymorphism,single nucleotide;
Diabetic nephropathies;
Uromodulin
- From:
Chinese Journal of Nephrology
2016;32(5):339-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of single nucleotide polymorphism (SNP) rs13333226 in uromodulin (UMOD) gene with diabetic kidney diseases (DKD) in Han population in Tianjin,China.Methods A total of 210 type 2 diabetes (T2DM),90 normal controls (NC) and 280 DKD patients were recruited.According to the level of estimated glomerular filtration rate (eGFR),the DKD subjects were further subdivided into three groups:GFR≥90 ml/min group (n=105),60 ml/mim≤GFR < 90 ml/min group (n=84) and GFR < 60 ml/min group (n=91).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for UMOD rs13333226C genotyping.Results The frequencies of AA,GA,GG genotype were 27.8%,58.9%,13.3% in NC group and 41.0%,48.6%,10.5% in T2DM group and 54.3%,36.1%,9.6% in DKD group.The frequency of G allele was 42.8% in NC group,34.8% in T2DM group and 27.7% in DKD group.The genotype distribution of UMOD was statistically significant between NC group and DKD group,and between T2DM group and DKD group (P < 0.05).G allele of UMOD was an independent protective gene polymorphism of DKD in Logistic regression (B=-0.248,Wald=8.012,P=0.021,OR=0.780,95% CI 0.612-0.968).Conclusion The G allele of UMOD gene may be an independent protective factor of DKD in Han population in Tianjin,China.