Comparisons of four equations to estimate glomerular filtration rate and their impacts on chronic kidney disease prevalence in community-dwelling elderly people in Beijing
10.3760/cma.j.issn.0254-9026.2016.02.017
- VernacularTitle:不同肾小球滤过率估测公式评估北京社区老年人群肾功能和慢性肾脏疾病患病率的差异
- Author:
Xuehan ZHANG
;
Haiyan XIE
;
Hong JIANG
;
Mingwei QIN
;
Dongjing LI
- Publication Type:Journal Article
- Keywords:
Glomerular filtration rate;
Kidney failure,chronic
- From:
Chinese Journal of Geriatrics
2016;35(2):179-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of four equations to estimate glomerular filtration rate (GFR) and their impacts on chronic kidney disease (CKD) prevalence in communitydwelling elderly people in Beijing.Methods A total of 489 participants aged above 70 years were enrolled.The GFR was estimated using the Cockcroft Gault (CG) equation,Chronic Kidney DiseaseEpidemiology Collaboration (CKD-EPI) equation,Modification of Diet in Renal Disease (MDRD) equation and Berlin Initiative Study (BIS) equation respectively.The internal-consistency check was made on the four equations for the GFR (ml min 1 1.73m 2) estimates.Results The mean age of participants was (81.8±7.6) years.The mean GFR estimated using the CG,CKD-EPI,MDRD and BIS equation was 58.4± 17.2,71.9± 15.3,76.7± 19.1 and 62.7± 12.7,respectively.And the prevalence of CKD was 56.2％,22.7％,17.8％ and 41.7％,respectively.The greatest differences of equations to estimate GFR were seen in elderly people aged 90 and above,and those with body mass index＜ 20.0 kg/m2 or serum creatinine concentration＜ 88.4 μmol/L.Conclusions The GFR estimated using different equations has a large difference which has a significant effect on CKD classification in elderly people.The equation to estimate GFR for the elderly is urgently needed.Until then,the eGFR and CKD classification estimated using different equations should be regarded with caution.
