The expression changes of human telomerase reverse transcriptase-mRNA and p53 protein in thyroid carcinoma tissues in the elderly and their clinical significance
10.3760/cma.j.issn.0254-9026.2016.02.015
- VernacularTitle:人端粒酶逆转录酶与p53蛋白在老年人甲状腺癌组织中的表达及临床意义
- Author:
Qing CHANG
;
Yaojie HU
;
Chunyou CHEN
;
Xin GUO
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Tumor suppressor protein p53
- From:
Chinese Journal of Geriatrics
2016;35(2):171-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression changes and significance of human telomerase reverse transcriptase (hTERT)-mRNA and mutant p53 protein in thyroid carcinoma tissues in the elderly.Methods The expression level of hTERT-mRNA was examined by in situ hybridization in 50 samples of thyroid carcinoma tissues from the elderly and 41 samples of thyroid carcinoma tissues from the non-elderly and 30 samples of thyroid benign lesions.The expression level of p53 was examined by immunohistochemistry in all subjects.Results The positive rate of hTERT-mRNA was 96.0％ (48/50),85.3％ (35/41) and 10.0％ (3/30) in thyroid carcinoma tissues from the elderly,the non-elderly and thyroid benign lesions respectively,and there were significant differences between the three groups (x2=73.61,P=0.000).The positive rate of p53 was 92.0％ (46/50),85.3％ (35/41) and 13.3％ (3/30) in thyroid carcinoma tissues from the elderly,the non-elderly and thyroid benign lesions respectively,and there were significant differences between the three groups (x2 =62.30,P =0.000).Conclusions The positive rates of hTERT-mRNA and p53 in thyroid carcinoma tissues are higher in the elderly than in the non-elderly,which can be used to evaluate the biological behavior and prognosis of thyroid carcinoma in the elderly,and they play the important roles for targeted therapy.
