Clinical analysis of the treatment on adenomyosis which is laparoscopic resection of the lesion combined with leuprolide release microspheres
10.3760/cma.j.issn.1008-6315.2016.04.027
- VernacularTitle:腹腔镜下病灶切除术联合醋酸亮丙瑞林缓释微球治疗子宫腺肌病临床分析
- Author:
Yanyan WANG
;
Li HUANG
;
Yanhua WANG
;
Hongmei LI
- Publication Type:Journal Article
- Keywords:
Adenomyosis;
Laparoscopy;
Resection of the lesion;
Gonadotropin-releasing hormone agonist
- From:
Clinical Medicine of China
2016;32(4):375-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of the treatment on adenomyosis which is laparoscopic resection of the lesion combined with leuprolide.Methods Eighty cases adenomyosis patients who have completed fertility and strongly urge to retain the uterus were selected,among them,42 cases chosed laparoscopic resection of lesions as the treatment (the control group) and 38 cases chosed surgical joint leuprolide release microspheres for 3 months as the treatment (the study group).The relieve dysmenorrhea,the menstrual flow,the uterine volume and the serum CA125 between the two groups were compared.Results After 6 months,uterine volume and menstruation of the study group were lower than those in the control group((128.5±45.1) cm3 vs.(149.2±48.5) cm3,(35.3±18.84) ％ vs.(5.2±23.5) ％),and the differences were significant(t =2.16,2.07,P＜0.05).After 12 and 18 months,the dysmenorrhea score,uterine volume,serum CA125 of the study group were lower than those in the control group(after 12 months:(1.5± 1.3) scores vs.(2.7±1.3) scores,(115.1±38.5) cm3 vs.(150.2±47.3) cm3,(30.2±13.6) U/ml vs.(60.5±26.3) U/ml;after 18 months:(1.7±1.5) scores vs.(2.9±1.9) scores,(122.2±44.6) cm3 vs.(157.5±48.6) ca3,(32.5±16.8) U/ml vs.(64.7±30.2) U/ml),and the differences were significant(t=4.12,3.11,3.62,3.37,8.97,7.71;P＜0.05).Conclusion The treatment of laparoscopic resection of the lesion adenomyosis joint leuprolide release microspheres on adenomyosis patients can improve the dysmenorrhea situation,reduce menstrual flow and the rate of disease recurrence after surgery,which is a worthy of clinical application treatment.
