Clinical value of procalcitonin detection in neonatal necrotizing enterocolitis
10.3760/cma.j.issn.1008-6315.2016.04.011
- VernacularTitle:降钙素原检测在新生儿坏死性小肠结肠炎中的临床价值
- Author:
Xiaoyan HU
;
Yuxin ZHOU
;
Songzhou XU
;
Yueyu LIN
;
Fang ZHAO
- Publication Type:Journal Article
- Keywords:
Procalcitonin;
Necrotizing enterocolitis;
Clinical value;
Neonate
- From:
Clinical Medicine of China
2016;32(4):325-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of of procalcitonin detection in neonatal necrotizing enterocolitis (NEC).Methods Sixty cases eligible NEC infants were randomly divided into observation group and control group(n=30 each group).All the infants were divided into Ⅰ grade group(19cases),Ⅱ-Ⅲ grade group(41 cases) according to NEC classification.All infants received PCT detection after NEC diagnosis.The observation group received antibiotic treatment base on the serum PCT levels.The control group received antibiotic treatment according to treatment routine and physician's clinical experience.Results PCT increased in 28 (46.7％) of the 60 NEC infants.In the Ⅰ grade group and Ⅱ-m grade group,the proportion of PCT increased cases were 26.3％,61.3％ respectively,and the PCTmax in PCT positive cases were (0.81±0.25) μg/L,(1.76±0.89) μg/L respectively,the differences were signifiacnt(x2 =4.627,t=-2.608,P＜0.05).The time of antibiotic usage in observation group was significantly less than that in control group ((4.9±3.0) d vs.(8.6±2.5) d,t=-3.645,P＜0.01).The fasting time and the cure time of the two groups had no significant difference (P＞ 0.05).Conclusion PCT detection can help to understand the cause and severity of NEC.Using antibiotics according to PCT levels can reduce the time of antibiotic usage without affecting the effect of the NEC treatment.
