Detection and clinical significance of anti-cardiolipin and anti-β2 glycoprotein Ⅰ antibodies in missed abortion women
10.3760/cma.j.issn.1008-6315.2016.04.006
- VernacularTitle:稽留流产患者抗心磷脂抗体和抗β2糖蛋白Ⅰ抗体的检测及临床意义
- Author:
Fang CHEN
;
Jie FANG
;
Ting WANG
;
Longfei XIA
;
Xiaoyan MA
;
Weidong SHI
;
Jian SUI
- Publication Type:Journal Article
- Keywords:
Missed abortion;
Anti-cardiolipin antibodies;
Anti-β2 glycoprotein Ⅰ antibodies
- From:
Clinical Medicine of China
2016;32(4):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of the anti-cardiolipin(aCL) antibodies and anti-β2 glycoprotein Ⅰ(anti-β2GPI) antibodies in missed abortion women.Methods Fourteen patients diagnosed missed abortion were chose as trial group,while 20 normal females received induced abortion in the same time as control group.Chemiluminescence method was used to measure the serum levels of IgG/IgM aCL and IgG/IgM anti-β2GPI antibodies in the two groups.Results The median levels of serum IgM aCL antibodies and serum IgM anti-β2GPI antibodies in trial group were significantly higher than those of control group(21.3(2.2-39.4)KU/L vs.6.0(1.5-10.7) KU/L,11.9(1.2-25.4) KU/L vs.1.9(1.1-4.0) KU/L;u=2.031,2.912;P ＜0.05).There were no significant differences in terms of the levels of serum IgG aCL antibodies and serum IgG anti-β2GPI antibodies between trial group and control group (P＞0.05).Conclusion There is correlation between IgM aCL as well as IgM anti-β2GPI antibodies and missed abortion,so in reducing the incidence of missed abortion,early and dynamic detection of anti-cardiolipin and anti-β2 glycoprotein I antibodies in childbearing women has a certain clinical significance.
