Effects of Dachengqi Decoction on Pulmonary Histology and Total IgE Levels in Mice with Allergic Asthma
10.3969/j.issn.1005-5304.2016.07.015
- VernacularTitle:大承气汤对过敏性哮喘小鼠肺组织形态及IgE水平的影响
- Author:
Daling ZHONG
;
Jiajia WU
;
Genmao LI
;
Dongyu GE
;
Jun WU
;
Guiying PENG
- Publication Type:Journal Article
- Keywords:
allergic asthma;
treatment of lung and large intestine;
Dachengqi Decoction;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(7):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects ofDachengqiDecoction on morphological changes, lung and spleen indexes, and total IgE levels of mice with allergic asthma; To discuss it relevant mechanism of action.MethodsThe method of OVA sensitization and provocation was used to establish allergic asthma mice models. 20 C57BL/6 mice were randomly divided into control group, model group,Dachengqi Decoction group and dexamethasone positive group. Each medication group was given relevant medicine for gavage. Lung and spleen indexes in each group were detected. The total IgE levels in serum of mice were detected by ELISA, and HE staining was used to conduct pathological observation.Results Compared with control group, the lung index and level of IgE in model group increased significantly and pulmonary histological results showed abundant inflammatory cells infiltrated in the bronchus; compared with the model group, the lung index as well as the levels of IgE decreased significantly in the Dachengqi Decoction and dexamethasone positive group (P<0.05), and the lung tissue organization form was improved significantly.ConclusionDachengqi Decoction has inhibiting effects on pulmonary inflammation of mice with asthma.
