Comparative Study on Pharmacokinetics of Components ofBuyang Huanwu Associated Prescriptions
10.3969/j.issn.1005-5304.2016.07.021
- VernacularTitle:补阳还五汤类方成分的药代动力学比较研究
- Author:
Fang LIU
;
Yantao YANG
;
Fuyuan HE
;
Lin LIU
;
Shuang WU
;
Yuhong WANG
;
Guangxian CAI
- Publication Type:Journal Article
- Keywords:
pharmacokinetics;
Buyang Huanwu Decoction;
Naojian Tablets;
ferulaic acid;
senkyunolide A;
ligustilide
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(7):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetic features of ferulaic acid, senkyunolide A and ligustilide in Buyang Huanwu associated prescriptions (Buyang HuanwuDecoction andNaojianTablets).MethodsHPLC-DAD was applied for simultaneous determination plasma concentration of three ingredients with jugular venous cannula rats after intragastric administration ofBuyang Huanwu associated prescriptions. The pharmacolinetic parameters of each ingredient was calculated by DAS2.0, and then the total quantum statistical moment (TQSM) standard similarity was used to measure the overall pharmacokinetics behaviors.Results There were great differences in the three ingredients after the administration of two prescriptions, while the total quantum statistical parameters were very closely. The TQSM pharmacokinetic parameters of the three components inBuyang HuanwuDecoction andNaojian Tablets showed that AUC, MRT, VRT were 240.6 and 133.0, 3.192 min and 3.259 min, 21.59 min2and 19.75 min2, respectively.The similarity was up to 0.977 8.Conclusion The metabolic processes in vivo ofBuyang Huanwu Decoction andNaojianTablets have similarities. The efficacy of Chinese herbal compounds mostly depends on the multi-components overall contributions.
