Effect of serum uric acid and its change on the incidence of nonalcoholic fatty liver disease
10.3760/cma.j.issn.1008-6315.2016.07.006
- VernacularTitle:血尿酸与非酒精性脂肪性肝病发生的关系
- Author:
Miao ZHANG
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
Uric acid;
Nonalcoholic fatty liver disease;
Incidence
- From:
Clinical Medicine of China
2016;32(7):597-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of serum uric acid ( UA ) level and its change in the incidence of nonalcoholic fatty liver disease( NAFLD) . Methods Subjects who participated in the adult health examination in a Top Three Hospital Medical Center of Guangzhou Province in 2012 and 2015, according to whether they have suffered from NAFLD after 3 years follow?up,were divide into NAFLD incidence group and negative control group. The data of anthropometry, laboratory examination and abdominal ultrasound were retrospective analyzed. Results There were 91 male in NAFLD incidence group and 317 males in negative control group. There were statistical significance in body weight ( Wt ) , BMI, UA, TG, HDL?C at baseline ( t=6. 10,4. 98,4. 21,1. 91,-4. 06;P<0. 05). According to UA<149 μmol/L,more than or equal to 149 to<416μmol/L,more than or equal to 416μmol/L as grouping standard,males detection of NAFLD in each group were 0 case,55 cases ( 19. 1%) , 36 cases ( 30. 3%) , and the difference was statistically significant compared with negative control group(χ2=6. 28,P=0. 012). According to UA<89 μmol/L,more than or equal to 89 to <357μmol/L,more than or equal to 357 μmol/L as grouping standard, females detection of NAFLD in each group were 0 case,91 cases( 20. 0%) ,39 cases( 37. 9%) ,and the difference was statistically significant compared with negative control group(χ2=14. 87,P=0. 001) . Age?adjusted partial correlation analyze showed that serum UA levels were positively correlated with Wt,BMI,SBP,DBP,BUN,SCr,ALT,TG and LDL?C levels,and negatively correlated with HDL?C levels( r=0. 349,0. 248,0. 152,0. 157,0. 201,0. 251,0. 132,0. 191,0. 148,-0. 228,P<0. 05) . There was no statistical significance between the NAFLD incidence group and the negative control group in the change of serum UA( z=0. 811,P=0. 417) . Binary Logistic regression analyze showed that the incidence of NAFLD was closely related to BMI,UA,ALT,TG and HDL?C at baseline,and the changes of Wt,ALT,TG, HDL?C during follow?up ( OR ( 95%CI ): 0. 767 ( 0. 709-0. 830 ) , 0. 996 ( 0. 994-0. 998 ) , 0. 964 ( 0. 937-0. 992),0. 702(0. 516-0. 955),4. 948(2. 414-10. 144),0. 890(0. 852-0. 930),0. 957(0. 937-0. 979), 0. 601(0. 441-0. 818),3. 111(1. 197-8. 080),P<0. 05). Conclusion Serum UA level is closely related to the incidence of NAFLD and its related risk factors, and serum UA level is an independent risk factor for NAFLD.
