Optimization of Prescription of Baichanting Tablets by Central Composite Design-Response Surface Methodology
10.3969/j.issn.1005-5304.2016.07.022
- VernacularTitle:星点设计-效应面法优化复方拜颤停片剂的处方
- Author:
Fang LU
;
Yuee JING
;
Yandong REN
;
Shuxiang ZHANG
;
Shumin LIU
- Publication Type:Journal Article
- Keywords:
Baichanting Tablets;
central composite design;
response surface methodology
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2016;23(7):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the prescription ofBaichanting Tablets by the central composite design-response surface methodology.Methods The doses of MCC, cCMC-Na, SiO2, and magnesium stearate were set as investigation factors; disintegration time and moisture rate were set as indexes. Linear equation quadratic polynomial described mathematic relationship of disintegration time and moisture rate with other four influence factors. Response surface was described according to the optimal mathematic models; the optimal prescription was chosen; predictive analysis was conducted.ResultsThe relationship of disintegration time and moisture rate with other four influence factors could not be described by linear equation. When quadratic polynomial matching was used, correlation coefficients were 0.837 9 and 0.923 1, with relatively high reliability. Optimal prescription contained 30.6%MCC, 10%cCMC-Na, 0.30%SiO2, and 0.10% magnesium stearate. The theoretical value and predicted value deviations of the disintegration time limit and moisture absorption rate were within 5%.Conclusion The predictability of the established model is good. Application of central composite design-response surface methodology can precisely optimize the prescription ofBaichanting Tablets.
