Distribution and changes in antimicrobial resistance of pathogens from blood culture in a tertiary first-class hospital in 2012-2015
10.3969/j.issn.1671-9638.2016.06.003
- VernacularTitle:2012-2015年某三甲医院血培养常见病原菌及其耐药性变迁
- Author:
Leping LIU
;
Wenen LIU
;
Qun YAN
;
Qingxia LIU
;
Mingxiang ZOU
;
Yanming LI
;
Hongling LI
- Publication Type:Journal Article
- Keywords:
bloodstream infection;
blood culture;
pathogen;
drug resistance;
drug resistance,microbial;
rational antimicrobial use
- From:
Chinese Journal of Infection Control
2016;15(6):374-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution and change in antimicrobial resistance of pathogens causing blood-stream infection,so as to provide reference for rational antimicrobial use.Methods The isolation and antimicrobial resistance of major pathogens from blood culture specimens from a tertiary first-class hospital in 2012-2015 were analyzed statistically.Results A total of 4 780 isolates were detected,the top five species were Escherichia coli (n = 1 008, 21.09%),Klebsiella pneumoniae (n = 624,13.05%),Acinetobacter baumannii (n = 452,9.46%),Staphylococcus aureus (n=437,9.14%),and Pseudomonas aeruginosa (n=247,5.17%).The percentage of gram-negative bacilli, gram-positive cocci,fungi,and others were 62.05%,29.31%,7.76%,and 0.88% respectively.The resistance rates of Klebsiella pneumoniae to ertapenem and imipenem increased from 4.50% in 2012 to 46.79% and 33.94% in 2015(both P<0.01).The resistance rates of Acinetobacter baumannii to cefepime,ceftazidime,tobramycin,gentamicin,and imipenem were 86.50%,80.56%,78.10%,79.87%,and 84.29% respectively;resistance rates to amikacin in 2012-2015 were 0, 10.22%,39.85%,and 21.30% respectively(P<0.01);resistance rates to minocycline in four years were 0-7.52% (P<0.01 ).Conclusion The main pathogens causing bloodstream infection are gram-negative bacilli,Acinetobacter baumannii is highly resistant to cephalosporins and carbapenems,resistance rates of Klebsiella pneumoniae to carbapenems increased rapidly.Broad-spectrum antimicrobial agents must be used cautiously to reduce the selective pressure of antimicrobial agents.