Soft composite materials for bone regeneration in vitro in skull repair
10.3969/j.issn.2095-4344.2016.25.009
- VernacularTitle:体外构建复合软质再生颅骨修复材料填充修复颅骨缺损
- Author:
Tongxing ZHANG
;
Hua GAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(25):3706-3712
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: In the process of bone defect repair, as their respective shortcomings, both autograft and al ograft cannot obtain satisfactory outcomes. OBJECTIVE: To observe the effect of soft composite materials for bone regeneration established in vitro in skul defect repair. METHODS: Soft composite materials for bone regeneration (bone morphogenetic protein 7-derived polypeptide, chitosan, nano hydroxyapatite and col agen) were established in vitro. Twenty-four Sprague-Dwley rats were enrol ed to prepare skul defect models, and were randomly equivalently divided into two groups. The rats were repaired with chitosan/nano hydroxyapatite/col agen composite materials as control group, and those repaired with soft composite materials of bone regeneration as experimental group. RESULTS AND CONCLUSION: The soft composite material of bone regeneration exhibited a loose and porous structure and bone morphogenetic protein 7-derived polypeptide was released in a gradual y rising trend. Compared with the control group, bone mineral density of the defect region in the experimental group was higher, which was similar with that of the normal bone tissue, and additional y numerous newborn bones could be found. These results show that the soft bone regeneration composite material exerts a better repair effect in skul defect.
