Influence of specific immunotherapy in allergic rhinitis children with different level of skin prick test with dermatophagoides allergens
10.16066/j.1672-7002.2016.06.011
- VernacularTitle:尘螨变应原皮肤点刺试验等级对特异性免疫治疗效果的影响
- Author:
Jiefeng GUO
;
Huiqing WU
;
Lili LIN
;
Xiaoming ZHAO
;
Binbin XIONG
;
Zhao LIU
- Publication Type:Journal Article
- Keywords:
Rhinitis,Allergic,Perennial;
Desensitization,Immunologic;
Skin Tests;
Treatment Outcome
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(6):345-348
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the efficacy of specific immunotherapy (SIT) with Alutard and NHD in children with allergic rhinitis due to different level of skin prick test (SPT) with dermatophagoides farinae (DF) and dermatophagoides pteronyssinus (DP). METHODS A total of 178 children with persistent allergic rhinitis were included in this study. Their age ranged from 6 to 12 years. They were divided into 3 groups according to level of SPT. Group 1: The level of skin index (SI) of DF is greater than that of DP, Group 2: The level of SI of DF is equal to that of DP and Group 3: The level of SI of DF is less than that of DP. The children in each group were randomly divided into 2 subgroups: Alutard group and NHD group. The children were given SIT with Alutard or NHD for one year. Symptom and medication scores were recorded and analyzed. RESULTS After receiving therapy for 3 months and 6 months, symptom and medication scores of the Group 1 and 2 in the NHD group were lower than those in the Alutard group (P<0.05); Symptoms and medication scores of the Group 3 in the Alutard group were lower than those in the NHD group (P<0.05). After receiving therapy for 9 and 12 months, the symptom and medication scores of the NHD and Alutard group in all the three groups showed no statistical difference (P>0.05). CONCLUSION The efficacy of SIT with Alutard and NHD is different in children with allergic rhinitis with different levels of SPT due to DF and DP after 3 and 6 months, but is similar after 9 and 12 months. SIT with Alutard and NHD is effective in treating children with allergic rhinitis.
