Expression of Maspin in invasive fungal rhinosinusitis

VernacularTitle:Maspin在侵袭型真菌性鼻-鼻窦炎中表达的研究
Author: Hewei YU ; Zonghui KANG ; Dan PAN ; Siwen XIA ; Xianhui HU ; Yingwu CHEN ; Yunsheng HE ; Yideng HUANG
Publication Type:Journal Article
Keywords: Immunohistochemistry; Mycoses; Sinusitis; invasive; Maspin
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2016;23(6):349-352
CountryChina
Language:Chinese
Abstract: OBJECTIVE To explore the expression of Maspin in invasive fungal rhinosinusitis (IFRS) and the value of Maspin in the diagnosis of IFRS. METHODS Forty two cases of fungal rhinosinusitis (FRS) were set as the experimental group, which included 12 cases of IFRS and 30 cases of noninvasive fungal rhino-sinusitis (NIFRS). At the same time, 30 cases of chronic rhino-sinusitis were set as control group. Immunohistochemistry (IHC) was used to detect the expression of Maspin. RESULTS Compared with the control group, the expression of Maspin in FRS group decreased statistically (t=-3.367, P<0.05). The IFRS group, compared with other two groups, had the lowest expression of Maspin (t=-3.390, P<0.05; t=-4.143, P<0.05). By using Maspin score of 5.70 as the cut-off point, the sensitivity and specificity for the diagnosis of IFRS was 91.7% and 88.3% respectively. CONCLUSION The expression of Maspin is very low in IFRS group. Down-regulation of Maspin expression may be a potential indicator for diagnosis of IFRS.