Association Study of TNF-αand ALCAM Polymorphisms with Chronic HCV Infection in Yunnan Han Population
- VernacularTitle:云南汉族人群TNF-α基因和ALCAM 基因多态性与HCV 慢性感染的相关性
- Author:
Chengxiu LIU
;
Yunsong SHEN
;
Yu ZHANG
;
Linping TAN
;
Yueting YAO
;
Jiankun YU
;
Taoyi LI
;
Yufeng YAO
;
Li SHI
- Publication Type:Journal Article
- Keywords:
HCV;
Chronic infection;
SNPs;
TNF-α;
ALCAM
- From:
Journal of Kunming Medical University
2016;37(5):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the association of allele polymorphisms SNP-rs1799724(C>T)in the TNF-αand SNP-rs11559013(G>A)in the ALCAM with HCV chronic infection in Han population in Yunnan province. Methods 434 HCV chronic infectious patients and 444 healthy individuals of Han Chinese population in Yunnan province were recruited. Two single nucleotide polymorphisms(SNPs)in the SNP-rs1799724(C>T) of TNF-αgene and SNP-rs11559013(G>A)of ALCAM gene were determined by real-time TaqMan polymerase chain reaction. We evaluated the associations of the two SNPs with HCV chronic infection. Results The distributions of allele and genotype of SNP-rs1799724(C>T)in the TNF-αand SNP-rs11559013(G>A)in the ALCAM between hepatitis C virus(HCV)chronic infectious patients and the healthy controls were not statistically significant(P > 0.05). Conclusion SNP-rs1799724(C>T)in the TNF-αand SNP-rs11559013(G>A) in the ALCAM have no association with HCV chronic infection in the Han population in Yunnan province.
