Artificial trachea with pedicle rib cartilage and cilia endothelial wall
10.16066/j.1672-7002.2016.04.008
- VernacularTitle:血管化肋软骨结合纤毛化内皮内壁的人工气管重建
- Author:
Xiujuan KOU
;
Xiaohong CHEN
;
Demin HAN
;
Yunlong BAI
;
Fanqian LU
- Publication Type:Journal Article
- Keywords:
Models,Animal;
Cilia;
Endothelium;
tracheal reconstruction;
artificial trachea
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(4):216-219
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo explore the method on reconstruction of long and special tracheal defects which can mostly match with natural airway: pedicle rib cartilage with cilia endothelial wall.METHODS8 experimental model of rabbits were trained with cervical double belt blood supply fascia embedding and autologous costal cartilage and nasal septum mucos in the first period, then followed by transplantation in the second period. After the operation, we would assess the physiology, breathing and histopathology index of the rabbits, etc. After the animal experiment, we tried to apply the method to an appropriate clinical case.RESULTS8 cases of experimental rabbits dead after the second period operation with the average survival time of 21.9 days and caused by asphyxia. Histopathological results: rib cartilage and trachea ring up of cartilage cells and fibers have high similarity in histology; cartilage of all cases under the cultivation of the pedicle fascial package has not been absorbed; all cases' nasal septum mucosa in the body and blood supply to differentiation under fascia nutrition. Then we applied the method on a clinical case.CONCLUSIONTrachea ring rib cartilage had a higher similarity to the tracheal cartilage on the histology and biological characteristics that can be used as the preparation of artificial trachea shaping material or cell culture to tissue engineering materials. Package of rib cartilage pedicle fascial can provide adequate blood supply to make up for a free training rib cartilage defect to its absorption. Nasal septum mucosa of pressure in the body and blood supply of the fascia nutrition can simulate the trachea ciliated epithelium, which can play its biological characteristics similar to the inner wall of the trachea.
