Effects of Compound Preparation of Fanshiliu on Lipid Metabolism and Pancreatic Pathological Changes in Type 2 Diabetes Mellitus Rats with Insulin Resistance
- VernacularTitle:复方番石榴制剂对2型糖尿病胰岛素抵抗大鼠脂肪代谢及胰腺组织病理形态的影响
- Author:
Hui LIN
;
Leyu LI
;
Quanxi MEI
;
Yuqiao GAO
;
Ying HU
;
Weibo DAI
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Compound preparation of Fanshiliu;
Insulin resistance;
Lipid metabolism;
Pathological morphology of pancreatic tissue
- From:
China Pharmacist
2016;19(5):866-869
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of compound preparation of Fanshiliu on lipid metabolism and pancreatic pathological changes in type 2 diabetes mellitus(T2DM)rats with insulin resistance. Methods:After fed with high-calorie food for 8 weeks,the rats received intraperitoneal injection with low dose of streptozotocin(STZ)to induce T2DM animal model,and then the rats were randomly divided into the model group,metformin group,high and low dose group of compound preparation of Fanshiliu. The normal group was given ordinary feed. The rats were sacrified after intragastric administration for six weeks,and fasted for 12 hours after the last administration. The lipid and lipoprotein indices were detected,and pathological morphology of pancreatic tissue was observed. Results:Compared with those in the model group,TC,TG,LDL-C and FFA in each treatment group were reduced,and HDL-C was increased(P < 0. 05). Fanshiliu high dose group and metformin group had obvious hypoglycemic and lipid-lowering effects. The results of pathological morphology of pancreatic tissue under a light microscope showed that the damage was the most obvious in the model group. Compound preparation of Fanshiliu groups and metformin group showed damage in varying degrees. Conclusion:Fanshiliu preparation can effectively adjust blood lipid levels,enhance the insulin sensitivity and reduce damage in pancreas in T2DM rats.
