Risk Factors Study for Lung Cancer Patients with Chemotherapy-induced Severe Neutropenia
- VernacularTitle:化疗致肺癌患者严重粒细胞减少相关危险因素研究
- Author:
Di FAN
;
Haisheng YOU
;
Sasa HU
;
Maoyi WANG
;
Weiyi FENG
;
Yalin DONG
- Publication Type:Journal Article
- Keywords:
Chemotherapy;
Neutropenia;
Lung cancer;
Risk factors
- From:
China Pharmacist
2016;19(5):896-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the risk factors in lung cancer patients with chemotherapy-induced severe neutropenia to provide reference for clinical drug use. Methods:A retrospective analysis was performed for the patients with lung cancer,and the risk factors of severe neutropenia were statistically analyzed and found out. Results:The results of single factor experiments showed that the incidence of severe neutropenia was related with radiotherapy history,cycles of chemotherapy and the use time of granulocyte colony factor. Based on a binary logistic regression analysis,the history of radiotherapy and the use of granulocyte colony factor were the significant risk factors of severe neutropenia in the lung cancer patients. Conclusion:For the patients with radiotherapy history,it is better to choose chemotherapy drugs with lower toxicity,decrease drug dosage or preventively use granulocyte colony factor. The rational use of rhG-CSF can alleviate chemotherapy-induced severe neutropenia.
