Clinical Observation of Piracetam Combined with Butylphthalide Soft Capsules in the Treatment of Patients with Lacunar Infarction Complicated with Vascular Cognitive Impairment
- VernacularTitle:吡拉西坦联合丁苯酞软胶囊治疗腔隙性脑梗死合并血管性认知功能障碍观察
- Author:
Youfeng ZHOU
- Publication Type:Journal Article
- Keywords:
Lacunar infarction;
Vascular cognitive impairment;
Butylphthalide soft capsules;
Piracetam tablets
- From:
China Pharmacist
2016;19(5):917-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy and safety of piracetam tablets combined with butylphthalide soft capsules in the treatment of patients with lacunar infarction(LI) complicated with vascular cognitive impairment(VCI). Methods:Totally 87 cases of patients with LI and VCI were selected and randomly divided into the control group(44 cases)and the treatment group(43 cases). The control group was only treated with piracetam tablets(1. 2 g,tid),while the treatment group was treated with piracetam tablets(1. 2 g,tid)and butylphthalide soft capsules(0. 2 g,qid),and the treatment course was 30 days. The changes of MMSE score,serum of SOD level and adverse drug reactions were observed and compared in the two groups. Results:Compared with those before the treatment,the mini-mental state examination(MMSE)score and serum level of SOD of the two groups were increased(P < 0. 01)after the treatment,and the increase in the treatment group was more notable than that in the control group(P < 0. 01and P < 0. 05). The effective rate of the treatment group was 86. 05% ,which was higher than that of the control group(75. 00% ,P < 0. 05). Conclusion:Piracetam combined with butylphthalide soft capsules can effectively improve the cognitive impairment of the patients with LI and VCI,and the effect may be related with increasing the level of SOD.
