Rapid Determination of Fifteen Elements in Ibuprofen Injection by ICP-MS
- VernacularTitle:电感耦合等离子质谱法快速测定布洛芬注射液中15种元素的含量
- Author:
Chunyi YAO
;
Biao LI
;
Haitao JIA
;
Chen YU
;
Jingya JU
;
Yujin LI
- Publication Type:Journal Article
- Keywords:
Inductively coupled plasma mass spectrometer;
Ibuprofen injection;
Elements
- From:
China Pharmacist
2016;19(5):1000-1003
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a method for the rapid determination of 15 elements such as Al,Ca,Cr,Mg,Zn,K,B,Sr, Cd,Ba,Pb,As,Sb,Na and Li in ibuprofen injection by ICP-MS. Methods:After diluted by 2% nitric acid solution,the samples was determined directly by inductively coupled plasma mass spectrometry(ICP-MS)with the online internal standard to correct matrix interference and signal drifting. Results:The detection limits of the method were ranged from 0. 031 to 5. 1 μg·L-1 . The average recoveries were within the range of 82. 6% -107% and RSDs were all less than 5% . Conclusion:The method is rapid, accurate and highly sensitive,which can provide technical support for the quality control of ibuprofen injection.
