Efifcacy of combined postauricular methylprednisolone injection and systemic therapy for profound Idiopathic sudden hearing loss
10.16066/j.1672-7002.2016.02.003
- VernacularTitle:耳后注射甲泼尼龙琥珀酸钠联合常规药物治疗重度突发性聋
- Author:
Hongguang JIA
;
Zhan YU
;
Xiaobing HUANG
- Publication Type:Journal Article
- Keywords:
Hearig Loss,Sudden;
Glucocorticoids;
Clinical Protocols;
postauricular injection
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(2):69-72
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo investigate the efficacy and the related complications of combinedpostauricular methylprednisolone injection and systemic therapy for profound idiopathic sudden hearing loss (ISSNHL). METHODSTotal of 60 patients with ISSNHLwho had received therapy from June 2014 to May 2015 in Beijing Anzhen Hospital affiliated to Capital University of Medical Science,were randomly divided into 2 groups,the systemic application group (30 patients): dexamethasone (DEX) was applied intravenously in dose of 10 mg×5 d, and the postauricular injection group (30 patients): methylprednisolone sodium suecinate was injected subperiosteally near the upper one-thirds of postauricular sulcus every day, 40 mg×5 d.All 60 patients received the same medications for 2 weeks to improve the hearing. Hearing and tympanic membrane were monitered before the injections and two weeks after the termination of injections. SPSS 16.0 software was used to analyze the data.RESULTSThe postauricular injection group: 23 of 30 ears had improvement of hearing. No related complications were reported. The systemic application group: 23 of 31 ears had improvement of hearing (P>0.05) No related complications were reported.CONCLUSIONCombined postauricular methylprednisolone injection and systemic medications therapy can be considered as is an effective therapy for profound idiopathic sudden hearing loss. It can avoid the side-effects of high dose systemic corticostemid treatment. For ISSNHL patients, postauricular methylprednisolone injection may be an appropriate treatment.
