Expression and diagnostic value of 34βE12, Galectin-3 and HBME-1 in thyroid nodules
10.16066/j.1672-7002.2016.02.008
- VernacularTitle:34βE12、Galectin-3及HBME-1在甲状腺良、恶性结节中的表达差异及临床诊断价值
- Author:
Jinwang DING
;
Rongjing ZHOU
;
Zhongyao LUO
;
Wei HE
;
Wo ZHANG
;
You PENG
;
Haifei ZHAO
;
Yiping XU
;
Gang PAN
;
Dingcun LUO
- Publication Type:Journal Article
- Keywords:
Thyroid Nodule;
Thyroid Neoplasms;
Diagnosis,Differential;
34βE12;
Galectin-3;
HBME-1
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(2):88-92
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo study the expressions of 34βE12, Galectin-3 and HBME-1 in thyroid nodules, and to explore its diagnostic value for papillary thyroid carcinoma (PTC).METHODSEn VisionTM immunohistochemical technique was used to detect the expression of 34βE12, Galectin-3 and HBME-1 in 352 thyroid lesions. The correlation between the expressions of the 3 protein markers and clinicopathological characteristics was evaluated. The receiver operating characteristic area under the curve (ROC-AUC) and their index for diagnosis evaluation were also calculated.RESULTSThe positive rates of 34βE12, Galectin-3 and HBME-1 in 246 PTC lesions were significantly higher than those in benign nodules (P<0.001). There was no relationship between the expression of the 3 protein markers and clinicopathological characteristics (eg. gender, age, numbers of lesions, tumor size, capsular invasion, lymph node metastasis, TNM staging). The ROC-AUC of 34βE12, Galectin-3 and HBME-1 for diagnosis of PTC was 0.936, 0.915 and 0.898 respectively. The sensitivity of 34βE12, Galectin-3 and HBME-1 for diagnosis of PTC was 94.3%, 95.5% and 91.1% respectively, while the specificity was 81.1%, 71.7% and 83.0% respectively, and the diagnostic accuracy rate was 90.3%, 88.4% and 88.6% respectively.CONCLUSION The expressions of 34βE12, Galectin-3 and HBME-1 are statistically different between PTC and benign lesions, but no associations are found with clinicopathological characteristics, indicating the three protein markers have important diagnostic value for PTC.
