Study of the therapeutic efficacy of Montelucast and Cetirizine on allergic rhinitis in children and their effects on the level of serum cytokines
10.16066/j.1672-7002.2016.02.013
- VernacularTitle:孟鲁司特联合西替利嗪治疗小儿变应性鼻炎的临床疗效及细胞因子水平的影响
- Author:
Luka ZHU
;
Lianfang YANG
;
Jingchan YAO
;
Guohua HU
- Publication Type:Journal Article
- Keywords:
Cetirizine;
Rhinitis,Allergic,Perennial;
Rhinitis,Allergic,Seasonal;
Cytokines;
Montelukast Sodium
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo study the therapeutic efficacy of Montelucast and Cetirizine on allergic rhinitis in children and their effects on the level of serum IFN-γ and IL-4.METHODS Sixty allergic rhinitis children were randomly divided into treatment group (30 children) and control group (30 children). The control group were treated with cetirizine drops (po, ages 2-6, 5 mg, qd, ages >6, 10 mg, qd.). Treatment group were treated with cetirizine drops combined with Montelucast (po, ages 2-5, 4 mg, qn, ages 6-12, 5 mg, qn, ages >12, 10 mg.). Thirty health children were selected as health group.RESULTSBefore treatment, the level of serum IFN-γ in treatment group and control group were significantly lower than that in health group (P<0.01), but the level of serum IL-4 were significantly higher than that in health group (the F was 19.25 and 143.81 respectively;P<0.01). Before treatment, there was no significant difference in the level of serum IFN-γ and IL-4 between treatment and control group (P>0.05). After treatment, the level of serum IFN-γ of both groups increased, and the level of serum IL-4 of both groups decreased. However, the level of serum IL-4 and IFN-γ in treatment group changed significantly (P<0.01). After treatment, VAS scores were lower than that of before treatment, however that of the treatment group was the lowest (P<0.01). After one month follow-up, there was no significant difference between the two groups.CONCLUSIONThe mechanism of Montelucast and cetirizine on treatment of allergic rhinitis may be related to the correction of the disorder of IFN-γ and IL-4.
