Effect of p38MAPK inhibitor on the soft palate reconstruction of the rats with chronic intermittent hypoxia
10.16066/j.1672-7002.2016.01.015
- VernacularTitle:p38丝裂原活化蛋白激酶信号通路抑制剂在慢性间歇性缺氧大鼠软腭重构作用的研究
- Author:
Liqiao GE
;
Ting MING
;
Jing YAN
;
Jin HOU
;
Nan GONG
;
Lin ZHAO
;
Fei WANG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Palate,Soft;
Immunohistochmistry;
p38 Mitogen-Activated Protein Kinases;
reconstitution
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the role of P38MAPK inhibitor on the soft palate reconstruction of the rats with chronic intermittent hypoxia. METHODS The animals were divided into normal control group, hypoxia control group and SB203580+hypoxia group (every group 20 rats). After 5 weeks, the expressions of p38MAPK and p-p38MAPK protein on the soft palate of the rats were detected with immunohistochemical techniques and western blot. RESULTS Compared with the normal control group, the soft palate tissue thickness of the hypoxia group were increased most obviously; Levels of p38MAPK were increased in hypoxia control group; Compared with the hypoxia control group, the levels of p-p38MAPK group were decreased in SB203580+hypoxia group. CONCLUSION p38MAPK may play important roles in the soft palate reconstruction of the rats with chronic intermittent hypoxia.