Identification of 17 Memory-enhancing Drugs Illegally Added in Traditional Chinese Medicines and Health Foods by LC-MS/MS
- VernacularTitle:液质联用法检查中成药及保健食品非法添加的17种辅助改善记忆类药物
- Author:
Huiyan LIU
- Publication Type:Journal Article
- Keywords:
LC-MS/ MS;
Multiple reactions monitoring(MRM);
Memory-enhancing drugs
- From:
China Pharmacist
2016;19(5):845-849
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop an LC-MS/ MS method for the analysis of 17 memory-enhancing drugs illegally added in tradi-tional Chinese medicines(TCM)and health foods. Methods:The method involved liquid chromatography-tandem mass spectrometry (LC-MS/ MS),and the separation was conducted on an Eclipse XDB C18 column(100 mm × 3. 0 mm,1. 8 μm). The 17 memory-en-hancing drugs illegally added in traditional Chinese medicines and health foods were analyzed by LC-MS/ MS with electrospray ioniza-tion(ESI)and multiple reactions monitoring(MRM). Results:A fast LC-MS/ MS method for the simultaneous screening of 17 illegal-ly added chemical components was described with the LOD below 10 ng·ml - 1 . Conclusion:The method is selective and sensitive in the detection of memory-enhancing drugs illegally added in traditional Chinese medicines and health foods.
