Preparation and Characteristics of Self-Emulsifying Drug Delivery System of Total Ginkgo Flavonoid
- VernacularTitle:银杏总黄酮自乳化释药系统的制备及其性质研究
- Author:
Xiangru LIAO
;
Qiongzhi SHI
;
Song FANG
;
Ying CHEN
- Publication Type:Journal Article
- Keywords:
Total ginkgo glavonoid;
Self-emulsifying drug delivery system;
In vitro dissolution
- From:
China Pharmacist
2016;19(5):850-853
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare total ginkgo flavonoid self-emulsifying drug delivery system(TGF-SMDDS)and estimate its char-acteristics in vitro. Methods:The formula of TGF-SMDDS was optimized based on the solubility tests,formula compatibility and microe-mulsion area in the pseudo ternary phase diagram. The appearance,morphology,particle size,zeta potential and in vitro dissolution of TGF-SMDDS were investigated. Results:The formula was composed of oleoyl macrogolglycerides as the oil phase,Tween-80 as the sur-factant and XCF as the co-surfactant. The ratio of oil phase,surfactant and co-surfactant was 10 ∶ 6 ∶ 4. The drug loading was 10. 0 mg· g -1 . After mixed with water,TGF-SMDDS was formed a clear and transparent microemulsion with homogeneous small spheres as seen un-der a transmission electron microscope. The particle size and zeta potential of TGF-SMDDS was(87. 4 ±26. 7)nm and( -13. 1 ±1. 5) mV,respectively. The accumulative dissolution of TGF-SMDDS in pH1. 2 hydrochloric acid solution was(96. 1 ±4. 8)% in 45 min. Con-clusion:The TGF-SMDDS can significantly enhance the dissolution of TGF in vitro,which may be a potential effective preparation for TGF.
