Effect of Naoxuekang Oral Liquid Combined with Nimodipine on Hypertensive Cerebral Hemorrhage and the Influence on Serum Tau Protein,IGF-1 and Hs-CRP in Patients
- VernacularTitle:脑血康口服液联合尼莫地平对高血压性脑出血疗效及患者血清 Tau 蛋白、IGF-1及 hs-CRP 的影响
- Author:
Yongqiang CAI
;
Zhaoqun XIAO
;
Jiajia RUAN
- Publication Type:Journal Article
- Keywords:
Naoxuekang oral liquid;
Hypertensive cerebral hemorrhage;
Tau protein;
Insulin-like growth factor -1;
Hypersensitive C-reactive protein
- From:
China Pharmacist
2016;19(5):904-907
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of Naoxuekang oral liquid combined with nimodipine on hypertensive cerebral hemorrhage and the influence on serum Tau protein,IGF-1 and hs-CRP in the patients. Methods:Totally 98 patients with hypertensive cerebral hemorrhage were randomly divided into two groups(n = 49). The patients in the control group were given nimodipine,while those in the observation group were given nimodipine and Naoxuekang oral liquid at the same time,and all the patients received 4-week treatment. The serum levels of Tau protein,IGF-1 and hs-CRP before and after the treatment were detected,and the national institutes of health stroke scale(NIHSS)score,hematoma volume and curative effect and adverse drug reaction were recorded as well. Results:Before the treatment,there was no significant differences in Tau protein,hs-CRP, IGF-1,NIHSS score and hematoma volume between the two groups(P > 0. 05). After the treatment,the levels of Tau protein and hs-CRP,NIHSS score and hematoma volume in both groups were decreased,and those in the observation group were lower than those in the control group;the IGF-1 level in both groups was increased,and that in the observation group was higher than that in the control group;and all the differences had statistical significance(P < 0. 05). There was no significant difference in the complication rate between the groups( P > 0. 05),while the effective rate of the observation group was significantly higher than that of the control group(89. 8% vs 73. 5% ,P < 0. 05). Conclusion:Naoxuekang oral liquid combined with nimodipine can significantly reduce the serum levels of Tau protein and hs-CRP,and increase the serum level of IGF-1,and improve the symptoms of patients with hypertensive cerebral hemorrhage,which is beneficial to the rehabilitation of patients.
