Determination of Th17-related cytokine interleukin17 in patients of chronic otitis media with effusion

VernacularTitle:慢性分泌性中耳炎中Th17相关细胞因子白介素-17的测定
Author: Caihong QIN ; Shouqin ZHAO ; Jie LI ; Yang WANG ; Lin YANG ; Ran REN
Publication Type:Journal Article
Keywords: Otitis Media with Effusion; Interleukin-17; Pathologic Processes; cytometric bead array
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2016;23(5):273-274
CountryChina
Language:Chinese
Abstract: OBJECTIVETo study the role of interleukin 17 (IL-17) in the pathogenesis of chronic otitis media with effusion (COME).METHODSThe expression of IL-17 in middle ear effusion (MEE) and blood plasma were measured in 30 patients (48 ears) by means of Cytometric Bead Array (CBA), as well as in 20 normal volunteers.RESULTSCompared with the control group, the level of IL-17 significantly increased in the peripheral blood of COME patients (P<0.05). What was more, the level of IL-17 in the MEE was higher than that in peripheral blood of COME patients (P<0.05).CONCLUSIONIL-17, as an important immunoregulatory mediator, may play an important role in chronic course of COME.