Glucocorticoid receptors mRNA expression in peripheral blood mononuclear cell in patients with obstructive sleep apnea hypopnea syndrome
10.16066/j.1672-7002.2016.03.012
- VernacularTitle:糖皮质激素受体mRNA在阻塞性睡眠呼吸暂停低通气综合征患者外周血单个核细胞中的表达
- Author:
Feng HE
;
Jingjia LI
;
Lihong CHANG
;
Zhaotong HUANG
;
Zhiyuan WANG
;
Pei LI
;
Haifeng WANG
;
Jin YE
- Publication Type:Journal Article
- Keywords:
Sleep Apnea,Obstructive;
Receptors,Glucocorticoid;
peripheral blood mononuclear cell
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2016;23(3):159-162
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo study the mRNA expression of glucocorticoid receptor(GR) in peripheral blood mononuclear cells in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and its clinical significance. METHODSReal-time fluorescent quantitative PCR was used to detect GRα mRNA and GRβ mRNA exprssion in PBMC of 30 male patients with moderate to severe OSAHS and 27 healthy male subjects. The relationships between the expression of glucocorticoid receptor mRNA and the apnea hypopnea index, body mass index, neck circumference, waist circumference, the lowest oxygen saturation, the average oxygen saturation, the Epworth sleepiness scale(ESS) score, fasting blood glucose, heart rate and blood pressure were analyzed.RESULTSCompared with the control group, the expression level of GRα mRNA was lower in the OSAHS group(t=2.25,P<0.05) and the expression level of GRβmRNA had no difference between the two groups(t=1.43, P>0.05). We had not found the significant correlation between the expression of GRα mRNA and the clinical parameters above in OSAHS patients.CONCLUSIONThe expression of GRα mRNA in PBMC in moderate to severe OSAHS male patients have a downward trend compared with healthy group, but the mechanism remains unclear.
