Antibacterial and Ultrastructure Effect of RES on Staphylococcus Aureus Standard Strains ATCC 2 5 9 2 3
10.3969/j.issn.1671-7414.2016.03.015
- VernacularTitle:白藜芦醇对金黄色葡萄球菌标准株抑菌作用及超微结构的影响
- Author:
Xin WANG
;
Rui ZHANG
;
Yajing LI
;
Qianqian DONG
- Publication Type:Journal Article
- Keywords:
resveratrol;
staphylococcus aureus;
antibacterial mechanism;
electron microscope
- From:
Journal of Modern Laboratory Medicine
2016;31(3):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antibacterial effect and mechanism of Resveratrol(RES)on Staphylococcus aureus stand-ard strains (ATCC 25923).Methods Using the microdilution protocol,to obtain minimal inhibitory concentrations(MIC)of RES on Staphylococcusaureus standard strains.Transmission electron microscope (TEM)and scanning electron microscope (SEM)were tested to obtain the effect of Staphylococcusaureus on Ultrastructure.Results The MIC of RES to Staphylo-coccusaureus standard strains ATCC 25923 were 0.256 mg/ml.Compared with control group,transmission electron and scanning electron microscope observation showed that after the act of RES on S.au standard strains,the cell morphology of S.au standard strains changed serious deformation,cells in all shapes and size,cell boundary roughness,cell wall defected and ruptured,and osteoporosis of edgeo,looseness of its structure,the nuclear membrane rupture,local showed vacuolar characteristics.Cell ultrastructure was obvious damaged and inhibition.Conclusion Rseveratrol had obvious inhibition and destruction to the standard strains of staphylococcus aureus,and the inhibition mechanism may be related to the destruction of cell membrane permeability.
