Research progress on anti-cancer effects of tuftsin and its derivatives
10.3969/j.issn.1001-1978.2016.06.002
- VernacularTitle:tuftsin及其衍生物T肽的抗癌作用研究进展
- Author:
Yinghong AN
;
Shoujun YUAN
- Publication Type:Journal Article
- Keywords:
tuftsin;
T peptide;
biological anticancer;
neutro-phils,;
macrophages;
biological response modifier(BRM)
- From:
Chinese Pharmacological Bulletin
2016;32(6):747-750
- CountryChina
- Language:Chinese
-
Abstract:
tuftsin,a physiologically active peptide,can promote phagocytosis,basically stimulates the macrophages or neutro-phils and improve their phagocytotic function.tuftsin can not di-rectly kill tumor cells.Due to its short structure and the charac-teristics of being susceptible to hydrolysis,it is difficult for tuft-sin to be made into medicine and applied clinically.However, derivatives of tuftsin-series and combination of tuftsin with other drugs can greatly enhance the cytotoxic effect on tumor cells of tuftsin.It has a broad prospect of research,especially deriva-tive-TP has a significant anti-tumor effect.Its mechanism is clear and its is expected to become a new type of anti-tumor bio-logical response regulator.
