Study of human telomere G4-DNA stabilizers
10.3969/j.issn.1001-1978.2016.06.003
- VernacularTitle:人体端粒G4-D NA稳定剂的研究进展
- Author:
Xiaohui ZHENG
;
Haiying LIU
;
Lixin XIA
;
Zongwan MAO
- Publication Type:Journal Article
- Keywords:
cancer;
telomere;
telomerase;
alternative lengthening of telomeres (ALT);
G-quadruplex DNA;
small organic mole-cules;
metal complexes
- From:
Chinese Pharmacological Bulletin
2016;32(6):751-755
- CountryChina
- Language:Chinese
-
Abstract:
Telomere maintenance plays a critical role in cancer progression.Approximately 85% human cancer cells maintain their telomere length through activation of telomerase.Other 15%of cancers maintain telomere length independently of telom-erase by alternative lengthening of telomeres (ALT)pathway. Both events are equally important for telomere length mainte-nance of cancer cells.Human telomere consists of a series of G rich DNA sequences,which could form G-quadruplex.The for-mation of this structure can block the extension of telomeres by telomerase or ALT,resulting in cancer cell death.Thereby,G-quadruplex has been one of the focuses of anticancer therapy in recent years.This review focuses on the latest progress of G-quadruplex stabilizers.
