Effect of hypoxic pulmonary vasoconstriction on hypoxic pulmonary hypertension
10.3969/j.issn.1001-1978.2016.06.007
- VernacularTitle:低氧性肺动脉高压中低氧性肺血管收缩的作用
- Author:
Xiangyun GAI
;
Pengcheng LIN
;
Yanfeng HE
;
Nanjia CAIRANG
- Publication Type:Journal Article
- Keywords:
hypoxic pulmonary vasoconstriction;
hypoxic pulmo-nary hypertension;
hypoxia;
high altitude sickness;
mechanism;
endothelial cells;
pulmonary artery smooth muscle cells
- From:
Chinese Pharmacological Bulletin
2016;32(6):768-772
- CountryChina
- Language:Chinese
-
Abstract:
Sustained hypoxic pulmonary vasoconstriction (HPV ) as experienced at high altitude can lead to hypoxic pulmonary hypertension(HPH).HPV,a special physiological phenomenon of lung,is the physiological reflex of organism in hypoxic envi-ronment.However,in high altitude hypoxic environment,the sustained HPV can lead to pulmonary vascular remodeling and right ventricular hypertrophy,at the same time,the degree of hypoxia in alveoli can be aggravated.Vicious circle of hypoxia is formed,further causing the severe high altitude sickness such as pulmonary edema and pulmonary heart disease.HPV appears in preliminary of HPH,but in the chronic phase,irreversible hy-poxic pulmonary vascular remodeling forms.Therefore,studying the mechanism of HPV and the effect of HPV in HPH can pro-vide targets and ideas for the prevention and treatment of high al-titude sickness. Additionally, in preliminary stage of HPV, prompt treatment is critical for the prevention of high altitude sickness.However,the mechanism of HPV and its roles in HPH are still not fully elucidated in current studies.This paper sum-marizes the studies about HPV in HPH of recent years,aiming to provide references for researchers and clinical treatment in this research field.
