Effects of rifampicin on hepatotoxicity and genes related to bile acid metabolism in mice
10.3969/j.issn.1001-1978.2016.06.020
- VernacularTitle:利福平对小鼠的肝毒性及胆酸代谢基因的影响
- Author:
Yongji XU
;
Wenkai LI
;
Jie LIU
;
Yuanfu LU
- Publication Type:Journal Article
- Keywords:
rifampicin;
hepatotoxicity;
bile acid me-tabolism;
cholestasis;
CYP7A1;
BSEP
- From:
Chinese Pharmacological Bulletin
2016;32(6):841-845
- CountryChina
- Language:Chinese
-
Abstract:
Aim Toexamineliverdamagebyrifampi-cin and hepatic gene expression related to bile acid me-tabolisminmice.Methods Adultmalemicewere given rifampicin(180 mg·kg-1 ,po)daily for 30 days and(90 mg·kg-1 ,po)daily for 90 days,blood bio-chemistry,histopathology,and gene expression were examined.Results Rifampicinincreasedanimalliver index and serum enzyme activities. Histopathology showed steatosis and spotted feathery-like degenera-tion.Rifampicin increased the expression of CYP7A1 after 30 and 90 days of administration,along with in-creased FXR and SHP.Rifampicin reduced the expres-sion of BSEP after 30 days of high dose administration. Conclusion Repeatedadministrationofrifampicin may cause liver injury and intrahepatic cholestasis in mice,and these effects are associated with the altera-tion of gene expression related to bile acid metabolism.
