Influence of methotrexate and etanercept on life quality in patients with ankylosing spondylitis
10.3760/cma.j.issn.1008-6706.2016.13.029
- VernacularTitle:甲氨蝶呤和依那西普对强直性脊柱炎患者生活质量的影响
- Author:
Jinjie WEN
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Life quality;
Etanercept;
Methotrexate
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(13):2027-2030
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the influence of methotrexate and etanercept on life quality of patients with ankylosing spondylitis.Methods 149 patients with ankylosing spondylitis were chosen,and they were treated with methotrexate and etanercept.The advances in imaging and life quality after 1 year were observed.Results After treatment for 12 months,X -ray of the hip joint showed that 38 cases of level 2 improved to level 1,16 cases of level 3 improved to level 2,and level 4 patients had no significant improvement.Each dimension of life quality of patients were significantly improved after treatment,the difference was statistically significant compared with before treatment (FRF =11.238,FBP =17.042,FRP =7.346,FGH =9.305,FVT =-5.811,FRE =6.529,FSF =7.018,FMH =14.203,P <0.05 ).After treatment,mSASSS increased to a certain extent,there was no significant difference compared with before treatment (F =0.194,P >0.05).BASDAI,PCS and MCS were all significantly improved,com-pared with before treatment,the differences were statistically significant (FBASDAI =3.871,FPCS =8.327,FMCS =6.191,P <0.05,P <0.05).There was no significant correlation between PCS and MCS and mSASSS (r =0.219, r =-0.118,P >0.05),but related to BASDAI(r =-0.792,r =-0.813,all P <0.05).Conclusion Methotrexate combined with etanercept could effectively control the clinical symptom of ankylosing spondylitis,and with good life quality,but patients with good quality still need X -ray follow up.
