Expression of Interleukin-1 9 and Its Relationship with Angiopathy in 2 Diabetes Mellitus

VernacularTitle:IL-19在2型糖尿病患者中的表达及与血管病变的关系
Author: Li LI ; Juanyu HU ; Zhengqing YU
Publication Type:Journal Article
Keywords: interleukin-1 9; type 2 diabetes mellitus; vascular complications
From: Journal of Modern Laboratory Medicine 2016;31(3):92-94
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of interleukin-19 (IL-19)and to investigate the relationship between IL-19 and type 2 diabetes mellitus9 (T2DM)with angiopathy.Methods IL-19,FBG,FINS and HbA1c were measured in 120 T2DM (including 32 patients with macroangiopathy,52 patients with microangiopathy and 36 without angiopathy)and 50 healthy subjects,the results were compared.Results Compared with control group,the level of IL-19 in T2DM (41.9 ± 11.9pg/ml vs 16.2±8.5pg/ml)was significantly higher than those of healthy subjects,and the difference was signifecant (t=7.56,P<0.05).The levels of IL-19 in T2DM with macroangiopathy or microangiopathy increased significantly in com-parison with those without angiopathy (t=4.57,3.26;all P<0.05),and closely correlated with the number of angiopathy. The level of IL-19 in T2DM was significantly positive correlated with HOMA-IR and HbA1c (r=0.523 and 0.491,P<0.01).Conclusion IL-19 level was significantly increased in patients with T2DM,and was closely related with HbA1c,insu-lin resistance,IL-19 may play acertain role in the pathogenesis of in T2DM with vascular complications.