Study on the Significance of Detecting MMP-1 0 Level in Patients with Type 2 Diabetic Nephropathy

VernacularTitle:2型糖尿病肾病患者检测血清基质金属蛋白酶-10的意义
Author: Hong WU
Publication Type:Journal Article
Keywords: metalloproteinase-10(MMP-10); diabetic nephropathy(DN); renal function
From: Journal of Modern Laboratory Medicine 2016;31(3):111-113
CountryChina
Language:Chinese
Abstract: Objective To explore the significance of detecting serum MMP-10 in type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groups,that was DM(42 cases)and DN(58 cases)group,and 60 casescontrolgroup(NC).By Mogenson,DN1(30 cases)and DN2(28 cases),HbA1c,BUN,Scr,UAER,β2-MG and MMP-10 leves were detected by the standard method.Results There were obvious differences of HbA1c,BUN,Scr,UAER,β2-MG and MMP-10 levels among DN,DM and NC(P<0.05).Apart of HbA1c,others were no differences between DM group and NC group(P>0.05).DN group was higher significantly than these in DM group(P<0.05),and HbA1c,BUN,Scr,UAER, andβ2-MG levels had no statistical difference between DN1 and DN2 group.MMP-10 level in DN2 was higher than that in DN1 group(P<0.05).Conclusion MMP-10 in serum may be a role indicator for impairment of renal function for diagnosis of type 2 diabetic nephropathy.