Anti-bacterial Effects of Baicalin on One Escherichia coli Strain Carrying NDM-1 Gene
10.3969/j.issn.1671-7414.2016.03.035
- VernacularTitle:黄芩苷对一株产NDM-1大肠埃希菌体内外抗菌作用的研究
- Author:
Zhiyuan LIU
;
Jian PAN
;
Jie QI
;
Tingju ZHANG
;
Yuzhi MA
- Publication Type:Journal Article
- Keywords:
baicalin;
Escherichia coli;
NDM-1;
anti-bacterial effects
- From:
Journal of Modern Laboratory Medicine
2016;31(3):124-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the bacteriostasis of baicalin against Escherichiacoli strain carrying NDM-1 gene.Methods Minimal inhibitory concentration(MIC)and minimal bactericidal concentration(MBC)were determined by broth dilution method.Synergy function was designed withcheckerboard method.Anti-infection effect in vivo of baicalin was observed in mice with bacteremia.Results In vitro antibacterial tests showed that the MIC and MBC baicalin were 8 mg/ml.Synergistic inhibitory effect was observed between baicalin and imipenem (FIC=0.125).In vivo inhibition experiments showed that ba-icalin had decreased the mortality of 25% of Escherichiacoli Strain carrying NDM-1 gene infection in mice.Conclusion Ba-icalin has antibacterial effect on NDM-1 E.coli.
