Regulatory effects of PB on sleep and wakefulness
10.3969/j.issn.1001-1978.2016.06.006
- VernacularTitle:臂旁核神经元调节睡眠觉醒的研究进展
- Author:
Minrui ZHAO
;
Dianru WANG
;
Jieren YANG
;
Yiqun WANG
- Publication Type:Journal Article
- Keywords:
parabrachial nucleus;
wakefulness;
NREM sleep;
REM sleep;
glutamatergic neuron;
projection
- From:
Chinese Pharmacological Bulletin
2016;32(6):764-767
- CountryChina
- Language:Chinese
-
Abstract:
The parabrachial nucleus (PB)is made up of gray matter around the Pons combination(BC),mainly consisting of glutamatergic,GABAergic and enkephalinergic neurons.PB is connected to hypothalamus and basal forebrain through a network of nerve fibers.Specific lesion of the entire parabrachial complex in animals leads to a deep coma.PB also projects to the non-rapid eye movement(NREM)-related regions including the ven-trolateral preoptic,and receives the projections from the parafa-cial zone.Activation of the GABAergic neurons in parafacial zone can promote NREM sleep,which indicates that PB partici-pates in NREM sleep.Furthermore,the lateral PB is actived when rapid eye movement(REM)sleep is deprived.In conclu-sion,PB participates in regulating wakefulness, NREM and REM sleep.This review summarizes the advances in the roles of PB in sleep-wake regulation.
