Effects of new drug T-006 on improving learning and memory abilities in scopolamine-induced dementia Kunming mice
10.3969/j.issn.1001-1978.2016.06.015
- VernacularTitle:新药T－006对东莨菪碱所致记忆障碍模型动物学习记忆的改善作用
- Author:
Qi SONG
;
Qin WANG
;
Weili WU
;
Min SHAO
;
Yu ZHANG
;
Zaijun ZHANG
;
Yuqiang WANG
;
Liang TAO
- Publication Type:Journal Article
- Keywords:
T-006;
scopolamine;
Morris water maze;
Kunming mice;
hippocampus;
cortex;
learning and memory abilities
- From:
Chinese Pharmacological Bulletin
2016;32(6):812-817
- CountryChina
- Language:Chinese
-
Abstract:
Aim ToexploretheeffectsofnewdrugT-006 on improving learning and memory abilities in scopolamine-induced dementia mice and its possible mechanism.Methods 72maleKunmingmicewere randomly divided into six groups:normal control group,model group,donepezil treatment group,T -006 treatment group with different doses(1,3 and 10 mg·kg-1 ).All mice were treated by intragastric ad-ministration for 14 consecutive days. Learning and memory abilities were tested by a five-day Morris water maze trial from the 1 1 th day.the first 4 days of the five-day Morris water maze,the navigation test was performed,the last day of Morris water maze is the spatial probe test.During the navigation test, mice were intraperitoneally given 2 mg · kg-1 scopolamine 20 minutes before entering the water,while normal control group mice administrated with sterile saline in-stead.Mice were not given T-006 nor scopolamine in spatial probe test.After Morris water maze,all mice were sacrificed for hippocampus and cortex.The activi-ties of AchE and SOD and the levels of GSH and MDA in hippocampus and cortex were measured after tissue harvesting.Results Comparedwithmodelgroup,T-006 could obviously improve learning and memory abil-ities in scopolamine-induced mice, significantly in-crease the levels of SOD and GSH and decrease the levelsofMDAandAchE.Conclusion T-006can significantly improve cognitive abilities in scopolamine-induced dementia mice,and its relevant mechanism may be closely related to its antioxidative effect and the ability to decrease AchE level.
