Assessing the Role of Matrix Metalloproteinase-9 in Rheumatoid Arthritis

VernacularTitle:基质金属蛋白酶-9在类风湿性关节炎中的诊断价值研究
Author: Shuilian OU ; Zhifeng PAN ; Zhuojun XU ; Yingliang LIANG ; Jingyi WU ; Heguo MO
Publication Type:Journal Article
Keywords: rheumatoid arthritis(RA); matrix metalloproteinase-9(MMP-9); rheumatoid factor(RF)
From: Journal of Modern Laboratory Medicine 2016;31(3):81-83
CountryChina
Language:Chinese
Abstract: Objective To assess the role of Matrix Metalloproteinase-9 (MMP-9)in rheumatoid arthritis (RA).Methods Peripheral blood from 45 RA patients and 28 healthy individuals (HV)were collected to detect RF and hs-CRP by immuno-turbidimetry,ESR by westergren method and MMP-9 by ELISA.The correlation was analysed between MMP-9 and RF, ESR or hs-CRP,respectively,by pearson correlation analysis.Results Levels of RF,ESR,hs-CRP and MMP-9 were signifi-cantly higher in RA patients than HV group (t=3.93~5.96,P<0.001),respectively.RF high titer patients or patients with a high inflammation response showed a higher MMP-9 levels than the RF low titer or slight inflammation patients (P<0.05).MMP-9 was positively correlated to RF,ESR and hs-CRP in RA patients(P<0.05),respectively.Conclusion MMP-9 maybe a sensitive tool in the diagnosis and management of RA patients.