Progress in the Research of Aquaporin-1 (AQP-1)of the Kidney
10.3969/j.issn.1671-7414.2016.03.046
- VernacularTitle:肾脏水通道蛋白-1（AQP-1）的研究进展
- Author:
Yiduo WANG
;
Yingyu JIN
;
Xiuru GUAN
- Publication Type:Journal Article
- Keywords:
aquaporin;
kidney disease
- From:
Journal of Modern Laboratory Medicine
2016;31(3):162-164
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin (AQP)is a molecular weight of about 28 kD of the four polymer structure membrane channel protein. In mammals,there are 1 3 different AQP,expressed in different tissues and organs,regulating waterand glycerol and urea and other small molecules transmembrane transport of major proteins.AQP-1 is mainly expressed in the renal proximal tubule and Henle’s loop drop bronchiole epithelial cell apical membrane and basement membrane,is responsible for the reabsorption of renal tubular water molecules.The expression of AQP-1 can be changed when the kidney is damaged or damaged,so it is very important to study the mechanism of AQP-1 for understanding the pathogenesis of water metabolism and the treatment of clinical water metabolism.
