Variation and Significance of Anticentromere Antibody(ACA) in Multi-Diseases

VernacularTitle:抗着丝点抗体在多种疾病中的变化和意义
Author: Xuemei XING ; Yanqin LI ; Gang SHEN ; Jun ZHANG ; Rong LI ; Yi LI ; Xiangdong LI
Publication Type:Journal Article
Keywords: anticentromere antibody; centromere protein B; autoimmune disease
From: Journal of Modern Laboratory Medicine 2016;31(3):88-91
CountryChina
Language:Chinese
Abstract: Objective To study the expression of anticentromere antibody (ACA)on multiple diseases to help the clinical diag-nosis and treatment.Methods The clinical and laboratory data of 129 cases with positive ACA were retrospectively ana-lyzed.Results ①116 females and 13 males were found among 129 cases with positive ACA,and serology titer of ACA in fe-male patients was higher than male and more compound antibody were shown in female patients,which was significantly dif-ferent compared with males (χ2=6.28,P=0.01;χ2=6.85,P=0.003).②Among 118 cases which had detailed clinical in-formation,there were 65 patients suffered from autoimmune diseases (55.08%)and 53 cases suffered from non-autoimmune diseases (44.92%).Autoimmune disease cases showed more compound and high serology titer,there were significant differ-ence between the two groups (χ2=21.97,P<0.001;χ2=11.44,P=0.001).Conclusion Though ACA was rarely found,it was shown in autoimmune and non-autoimmune diseases and can be not too severe or fetal and even lead to multi-organ fail-ure.So it should be taken seriously.